Jaringan Laboratorium Medis

Vol. 5 No. 2 (2023): November 2023
Original Articles

The Relationship of Zink and Iron Levels with Blood Pressure in Pulmonary Tuberculosis Patient

Dewi Kurniasih
Poltekkes Kemenkes Jambi
Muslina
Poltekkes Kemenkes Jambi
Aminahtun Latifah
Poltekkes Kemenkes Jambi
Dina Afrianti
Poltekkes Kemenkes Semarang

Published 2023-11-01

Keywords

  • Zinc,
  • Iron,
  • Blood pressure,
  • Pulmonary TBC

How to Cite

The Relationship of Zink and Iron Levels with Blood Pressure in Pulmonary Tuberculosis Patient. (2023). Jaringan Laboratorium Medis, 5(2), 120-128. https://doi.org/10.31983/jlm.v5i2.10415

CrossMark



Dimensions

If it doesn't Appear, click here



PlumX Metrics



Impact Factor

or, Visit on here

Abstract

Background: Mycobacterium tuberculosis infection in Tuberculosis (TBC) causes narrowing of the pulmonary blood vessels and triggers pulmonary hypertension which is associated with iron deficiency and anemia. The mineral zinc (Zn) is known to play an important role in destroying the bacteria that cause TBC. In addition, iron (Fe) deficiency in TBC patients can cause relapse and even treatment failure. This study aims to examine the relationship between serum zinc and iron levels and blood pressure in pulmonary TBC patients. Method: A descriptive analytical observational study with a cross sectional design was conducted on 51 TBC patients undergoing treatment at the Simpang IV Sipin Community Health Center, Jambi City. Using a purposive sampling technique, respondents who met the research inclusion and exclusion criteria were examined for zinc and Fe levels. The examination was carried out at the Jambi Province Regional Health Laboratory, the examination result data was then analyzed bivariately using the chi square test. Results: The results of statistical analysis between blood pressure and Zn levels obtained a significant value with P value = 0.877 and a significant value for Fe levels obtained P value = 0.841 (> 0.05). Conclusion: There is no significant relationship between Zn and Fe levels and blood pressure in pulmonary TBC patients. Based on research, it is known that iron deficiency and anemia are not directly related to pulmonary hypertension which can be experienced by TBC patients.

Downloads

Download data is not yet available.

References

  1. Aditama, T. Y. (2010). Penanggulangan Tuberculosis Paru. UI.
  2. Ali, W., Ahmad, I., Srivastava, V., Prasad, R., Kushwaha, R. A., & Saleem, M. (2014). Serum zinc levels and its association with vitamin A levels among tuberculosis patients. Journal of Natural Science, Biology and Medicine, 5(1), 130–134. https://doi.org/10.4103/0976-9668.127310
  3. Ariani, F., Lapau, B., Zaman, K., Mitra, M., & Rustam, M. (2022). Faktor-Faktor Yang Berhubungan Dengan Kejadian Tuberkulosis Paru. Jurnal Bahana Kesehatan Masyarakat (Bahana of Journal Public Health), 6(1), 33–38. https://doi.org/10.35910/jbkm.v6i1.560
  4. Baraskar, V. J., & Shinde, P. P. (2018). Role of Zinc in Pulmonary Tuberculosis. Journal of Evidence Based Medicine and Healthcare, 5(17), 1431–1434. https://doi.org/10.18410/jebmh/2018/299
  5. Boloorsaz, M. R., Khalilzadeh, S., Milanifar, A. R., Safavi, A., & Velayati, A. A. (2007). Impact of anti-tuberculosis therapy on plasma zinc status in childhood tuberculosis. Eastern Mediterranean Health Journal, 13.
  6. Brunner, & Suddarth. (2010). Keperawatan Medikal bedah (Vol 1). EGC.
  7. Carpenter, W. E., Lam, D., Toney, G. M., Weintraub, N. L., & Qin, Z. (2013). Zinc, copper, and blood pressure: Human population studies. Medical Science Monitor, 19(1), 1–8. https://doi.org/10.12659/MSM.883708
  8. Chababa, L., Mukosha, M., Sijumbila, G., & Vwalika, B. (2016). Relationship between serum zinc levels and preeclampsia at the University Teaching Hospital, Lusaka, Zambia. Medical Journal of Zambia, 43(3), 139–144.
  9. Fauziani, A., Hidajat, N. N., Ramdan, A., & Rahim, A. H. (2020). Iron as Preoperative Antituberculosis Supplement Increases Interleukin-12 Level in Spinal Tuberculosis and Iron Deficiency Patients. Jurnal Anestesi Perioperatif, 8(1), 17–23. https://doi.org/10.24036/perspektif.v4i4.466
  10. Ghulam, H., Kadri, S. M., Manzoor, A., Waseem, Q., Aatif, M. S., Khan, G. Q., & Manish, K. (2009). Status of zinc in pulmonary tuberculosis. Journal of Infection in Developing Countries, 3(5), 365–368. https://doi.org/10.3855/jidc.244
  11. Harfiani, E., . M., & Nurhakim, A. D. (2020). Faktor Apa Yang Mempengaruhi Rendahnya Tingkat Pengobatan Tuberkulosis di Lagoa Jakarta? JURNAL ILMIAH KESEHATAN MASYARAKAT : Media Komunikasi Komunitas Kesehatan Masyarakat, 12(3), 110–117. https://doi.org/10.52022/jikm.v12i3.80
  12. Hussain, M. A., Al Mamun, A., Reid, C., & Huxley, R. R. (2016). Prevalence, awareness, treatment and control of hypertension in Indonesian adults aged ≥40 years: Findings from the Indonesia Family Life Survey (IFLS). PLoS ONE, 11(8), 1–16. https://doi.org/10.1371/journal.pone.0160922
  13. Kemenkes RI. (2019). Hipertensi Penyakit Paling Banyak Diidap Masyarakat. Kementerian Kesehatan RI. https://www.kemkes.go.id/article/view/19051700002/hipertensi-penyakit-paling-banyak-diidap-masyarakat.html
  14. Kemenkes RI. (2023). Pemerintah Fokuskan Penanganan TBC pada Pekerja. Biro Komunikasi & Pelayanan Publik Kementerian Kesehatan RI. https://sehatnegeriku.kemkes.go.id/baca/rilis-media/20230317/1542598/pemerintah-fokuskan-penanganan-tbc-pada-pekerja/#:~:text=Berdasarkan Global TB Report tahun,dimana mayoritas orang%2Dorang bekerja.
  15. Kemenkes, R. (2018). Hasil Riset Kesehatan Dasar Tahun 2018. In Kementerian Kesehatan RI.
  16. Kumar, N. P., Banurekha, V. V, Nair, D., Dolla, C., Kumaran, P., & Babu, S. (2018). Modulation of iron status biomarkers in tuberculosis-diabetes co-morbidity. Tuberculosis (Edinb), 3, 127–135. https://doi.org/10.1016/j.tube.2017.11.011.Modulation
  17. Mandieka, E., Saleh, D., Chokshi, A. K., Rivera, A. S., & Feinstein, M. J. (2020). Latent tuberculosis infection and elevated incidence of hypertension. Journal of the American Heart Association, 9(24), 9–11. https://doi.org/10.1161/JAHA.120.019144
  18. Mishra, S., Pallavi Taparia, M., Koolwal, S., & Scholar, P. (2018). Study of iron metabolism in pulmonary tuberculosis patients. International Journal of Health Sciences & Research, 8(March), 70–77.
  19. Neves, J., Haider, T., Gassmann, M., & Muckenthaler, M. U. (2019). Iron homeostasis in the lungs—A balance between health and disease. Pharmaceuticals, 12(1), 1–28. https://doi.org/10.3390/ph12010005
  20. Nuraili, M. P., Respati, T., & Indrayana, E. S. (2020). Gambaran BMI dan Tekanan Darah pada Penderita Tuberkulosis dan Non Tuberkulosis di Desa Pangalengan. Jurnal Integrasi Kesehatan & Sains, 2(2), 150–153. https://doi.org/10.29313/jiks.v2i2.6420
  21. Pilakkadavath, Z., & Shaffi, M. (2016). Modifiable risk factors of hypertension: A hospital-based case-control study from Kerala, India. Journal of Family Medicine and Primary Care, 5(1), 114. https://doi.org/10.4103/2249-4863.184634
  22. Prasad, A. S. (2014). Impact of the discovery of human zinc deficiency on health. Journal of Trace Elements in Medicine and Biology, 28(4), 357–363. https://doi.org/10.1016/j.jtemb.2014.09.002
  23. Ramakrishnan, K., Rajaiah, S., Karuppusamy, K., Alagappa, U., Ramakrishnan, B., & Ponniah, T. (2008). Serum Zinc and Albumin Levels in Pulmonary Tuberculosis Patients With and Without HIV. Japanese Journal of Infectious Diseases, 61(3), 202–204.
  24. Ravimohan, S., Kornfeld, H., Weissman, D., & Bisson, G. P. (2018). Tuberculosis and lung damage: From epidemiology to pathophysiology. European Respiratory Review, 27(147). https://doi.org/10.1183/16000617.0077-2017
  25. Sarwar, M. S., Ahmed, S., Ullah, M. S., Kabir, H., Rahman, G. K. M. M., Hasnat, A., & Islam, M. S. (2013). Comparative Study of Serum Zinc, Copper, Manganese, and Iron in Preeclamptic Pregnant Women. Biological Trace Element Research, 154(1), 14–20. https://doi.org/10.1007/s12011-013-9721-9
  26. Susiwati, & Anggita. (2017). Hubungan Lama Waktu Paparan Polutan Terhadap Kadar SGPT Pada Penyapu Jalan Sore Hari Di Kota Bengkulu. Journal of Nursing and Public Health, 5(2), 95–100.
  27. Wang, Y., & Wang, J. (2020). Modelling and prediction of global non-communicable diseases. BMC Public Health, 20(1), 1–13. https://doi.org/10.1186/s12889-020-08890-4
  28. Waworuntu, W., Tanoerahardjo, F. S., Mallongi, A., Ahmad, A., Amin, M., Djaharuddin, I., Bukhari, A., Tabri, N. A., Bahar, B., Hidayah, N., Halik, H., & Massi, M. N. (2023). Serum iron levels in tuberculosis patients and household contacts and its association with natural resistance-associated macrophage protein 1 polymorphism and expression. Clinical Respiratory Journal, 17(9), 893–904. https://doi.org/10.1111/crj.13677
  29. Wessels, I., Maywald, M., & Rink, L. (2017). Zinc as a gatekeeper of immune function. Nutrients, 9(12), 9–12. https://doi.org/10.3390/nu9121286
  30. WHO. (2013). World Health Statistic 2013. In World Health Organization.
  31. WHO. (2022a). Global Tuberculosis Report 2022.
  32. WHO. (2022b). Tuberculosis. World Health Organization. https://www.who.int/indonesia/news/campaign/tb-day-2022/fact-sheets
  33. WHO. (2023). Hypertension. World Health Organization. https://www.who.int/news-room/fact-sheets/detail/hypertension
  34. Wu, C. Y., Hu, H. Y., Chou, Y. J., Huang, N., Chou, Y. C., & Li, C. P. (2015). High blood pressure and all-cause and cardiovascular disease mortalities in community-dwelling older adults. Medicine (United States), 94(47), e2160. https://doi.org/10.1097/MD.0000000000002160
  35. Yılmaz, S., Calikoglu, E. O., & Kosan, Z. (2019). for an Uncommon Neurosurgical Emergency in a Developing Country. Nigerian Journal of Clinical Practice, 22, 1070–1077. https://doi.org/10.4103/njcp.njcp